Comparative host transcriptome in response to pathogenic fungi identifies common and species-specific transcriptional antifungal host response pathways

Candidiasis, aspergillosis, and mucormycosis cause the majority of nosocomial fungal infections in immunocompromised patients. Using an unbiased transcriptional profiling PBMCs exposed to species causing these infections, we found a core host response healthy individuals that may govern effective clearance: it consists 156 transcripts, involving canonical non-canonical immune pathways. Systematic investigation key steps antifungal defense revealed fungal-specific signatures. As previously demonstrated, Candida albicans induced type I Type II interferon-related In contrast, central pattern recognition receptor, reactive oxygen production, glycolytic pathways were down-regulated Rhizopus oryzae, which was associated with ER-stress response. TLR5 identified be uniquely regulated by Aspergillus fumigatus control cytokine release this fungus. conclusion, our data reveals profiles C. albicans, A. fumigatus, R. describes both common specific responses could exploited for novel therapeutic strategies.